Pediatric Recurrent Syncope and Neurally Mediated Hypotension

Journal Article Abstracts 

• Reviews
  
• HUT and Diagnosis
  
• Cerebral Blood Flow Changes
  
• Other Testing
  
• Exercise-Related Syncope
  
• Course and Outcome
  
• Therapy
  
• Families
  
• Psychology
  

Reviews

• Sapin SO. Autonomic syncope in pediatrics: a practice-oriented approach to classification, pathophysiology, diagnosis, and management. Clin Pediatr (Phila). 2004 Jan-Feb;43(1):17-23.
  
  
• Boehm KE, Morris EJ, Kip KT, Karas B, Grubb BP. Diagnosis and management of neurally mediated syncope and related conditions in adolescents.
  J Adolesc Health. 2001 Jan;28(1):2-9. Review. No abstract available.
  
  
• Johnsrude CL. Current approach to pediatric syncope. Pediatr Cardiol. 2000 Nov-Dec;21(6):522-31. Review.
  
  
• Grubb BP. Cerebral syncope: new insights into an emerging entity. J Pediatr. 2000 Apr;136(4):431-2. Review. Editorial. Full article available for free. 
  
  
• Grubb BP. Pathophysiology and differential diagnosis of neurocardiogenic syncope. Am J Cardiol. 1999 Oct 21;84(8A):3Q-9Q. Review.
  
  
• Wieling W, Smit AA, de Jong-de Vos van Steenwijk CC, van Lieshout JJ, Karemaker JM. Pathophysiological mechanisms underlying vasovagal syncope in young subjects. Pacing Clin Electrophysiol. 1997 Aug;20(8 Pt 2):2034-8. Review.
  
  
• Balaji S, Oslizlok PC, Allen MC, McKay CA, Gillette PC  Neurocardiogenic syncope in children with a normal heart. J Am Coll Cardiol. 1994 Mar 1;23(3):779-85
  
  
  
  

Head-up Tilt Table Testing and Diagnosis

• Arnaiz P, Dumas E, Heusser F, Gonzalez R, Jalil J. Effects of Tilt Test and Beta-Adrenergic Stimulation on the QT Interval in Normal Children and Pediatric Patients With Unexplained Syncope. Rev Esp Cardiol. 2004 Feb;57(2):173-6. English, Spanish.
  
  
• Dindar A, Cetin B, Ertugrul T, Cantez T. Sublingual isosorbide dinitrate-stimulated tilt test for diagnosis of vasovagal syncope in children and adolescents. Pediatr Cardiol. 2003 May-Jun;24(3):270-3. Epub 2003 Mar 14.
  
  
• Stewart JM, Weldon A. Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope. Clin Sci (Lond). 2003 Apr;104(4):329-40.
  
  
• Moak JP, Bailey JJ, Makhlouf FT. Simultaneous heart rate and blood pressure variability analysis. Insight into mechanisms underlying neurally mediated cardiac syncope in children. J Am Coll Cardiol. 2002 Oct 16;40(8):1466.
  
  
• Kilic A. Dysrhythmia as a cause of syncope in children without neurological or cardiac morphological abnormalities. Pediatr Int 2002 Aug;44(4):358-62.
  
  
• Sung RY, Yu CW, Ng E, Du ZD, Tomlinson B, Tam MS. Head-up tilt test without intravascular cannulation in children and adolescents. Int J Cardiol. 2001 Aug;80(1):69-76.
  
  
• McGavigan AD, Hood S. The influence of sex and age on response to head-up tilt-table testing in patients with recurrent syncope.
  Age Ageing. 2001 Jul;30(4):295-8.
  
  
• Massin MM, Henrard V, Gerard P. Heart rate variability and the outcome of head-up tilt in syncopal children.
  Acta Cardiol. 2000 Jun;55(3):163-8.
  
  
• Eltrafi A, King D, Silas JH, Currie P, Lye M. Role of carotid sinus syndrome and neurocardiogenic syncope in recurrent syncope and falls in patients referred to an outpatient clinic in a district general hospital.
  Postgrad Med J. 2000 Jul;76(897):405-8.
  
  
• Massin MM, Leroy P.A 9-year-old girl with chronic fatigue. Diagnosis: neurally mediated hypotension.
  Eur J Pediatr. 1999 Sep;158(9):761-2. No abstract available.
  
  
• Salim MA, Ware LE, Barnard M, Alpert BS, DiSessa TG. Syncope recurrence in children: relation to tilt-test results.
  Pediatrics. 1998 Oct;102(4 Pt 1):924-6.
  
  
• Stewart J, Weldon A, Arlievsky N, Li K, Munoz J. Neurally mediated hypotension and autonomic dysfunction measured by heart rate variability during head-up tilt testing in children with chronic fatigue syndrome.
  Clin Auton Res. 1998 Aug;8(4):221-30
  
  
• Tanaka H, Yamaguchi H, Tamai H, Mino M, Konishi K, Thulesius  Haemodynamic changes during vasodepressor syncope in children and autonomic function. Clin Physiol. 1997 Mar;17(2):121-33.
  
  
• Lenk MK, Alehan D, Ozme S, Celiker A, Ozer S. Vasovagal syncope: asystole provoked by head-up tilt testing under sertraline therapy.
  Turk J Pediatr. 1997 Oct-Dec;39(4):573-7.
  
  
• Rowe PC, Bou-Holaigah I, Kan JS, Calkins H. Is neurally mediated hypotension an unrecognised cause of chronic fatigue?
  Lancet. 1995 Mar 11;345(8950):623-4.
  
  
• Strieper MJ, Auld DO, Hulse JE, Campbell RM. Evaluation of recurrent pediatric syncope: role of tilt table testing.
  Pediatrics. 1994 Apr;93(4):660-2.
  
  
• Ovadia M, Thoele D. Esmolol tilt testing with esmolol withdrawal for the evaluation of syncope in the young.
  Circulation. 1994 Jan;89(1):228-35.
  
  
• Grubb BP, Temesy-Armos PN, Samoil D, Wolfe DA, Hahn H, Elliott L. Tilt table testing in the evaluation and management of athletes with recurrent exercise-induced syncope.
  Med Sci Sports Exerc. 1993 Jan;25(1):24-8.
  
  
• Samoil D, Grubb BP, Kip K, Kosinski DJ. Head-upright tilt table testing in children with unexplained syncope. Pediatrics. 1993 Sep;92(3):426-30. Review.
  
  
• Fish FA, Strasburger JF, Benson DW Jr. Reproducibility of a symptomatic response to upright tilt in young patients with unexplained syncope.
  Am J Cardiol. 1992 Sep 1;70(6):605-9.
  
  
• Grubb BP, Temesy-Armos P, Moore J, Wolfe D, Hahn H, Elliott L. The use of head-upright tilt table testing in the evaluation and management of syncope in children and adolescents.
  Pacing Clin Electrophysiol. 1992 May;15(5):742-8.
  
  
• Grubb BP, Orecchio E, Kurczynski TW. Head-upright tilt table testing in evaluation of recurrent, unexplained syncope.
  Pediatr Neurol. 1992 Nov-Dec;8(6):423-7. Review.
  
  
• Ross BA, Hughes S, Anderson E, Gillette PC. Abnormal responses to orthostatic testing in children and adolescents with recurrent unexplained syncope.
  Am Heart J. 1991 Sep;122(3 Pt 1):748-54.
  
  
• Pongiglione G, Fish FA, Strasburger JF, Benson DW Jr. Heart rate and blood pressure response to upright tilt in young patients with unexplained syncope. J Am Coll Cardiol. 1990 Jul;16(1):165-70.
  
  
• Pratt JL, Fleisher GR. Syncope in children and adolescents. Pediatr Emerg Care. 1989 Jun;5(2):80-2.

Cerebral Blood Flow Changes

• Grubb BP. Cerebral syncope: new insights into an emerging entity. J Pediatr. 2000 Apr;136(4):431-2. Review. No abstract available. Full article available for free. 
  
  
• Shimizu H, Sumi K, Sugita T, Abe J, Futagi Y, Mimaki T, Yabuuchi H. Cerebral blood flow changes in orthostatic dysregulation fainters.
  Brain Dev. 1982;4(1):21-6.
  
  
• Kojo M, Wada M, Akiyoshi K, Inutsuka M, Izumi T. Reduction of carotid artery blood flow in pediatric patients with syncope: evaluation with head-up tilt test.
  Neuropediatrics. 2001 Aug;32(4):169-75.
  
  

Other Testing

• Saarel EV, Stefanelli CB, Fischbach PS, Serwer GA, Rosenthal A, Dick M 2nd. Transtelephonic electrocardiographic monitors for evaluation of children and adolescents with suspected arrhythmias. Pediatrics. 2004 Feb;113(2):248-51.
  
  
• Tanaka H, Thulesius O, Yamaguchi H, Mino M. Circulatory responses in children with unexplained syncope evaluated by continuous non-invasive finger blood pressure monitoring.
  Acta Paediatr. 1994 Jul;83(7):754-61.
  
  
• Perry JC, Garson A Jr. The child with recurrent syncope: autonomic function testing and beta-adrenergic hypersensitivity.
  J Am Coll Cardiol. 1991 Apr;17(5):1168-71.
  
  
• Uchiyama M, Otsuka T, Sakai K. Response of plasma renin activity to postural change in vasovagal syncope in children, with observations on syncope. Horm Res. 1986;23(3):147-50.
  
  

Exercise- or Stretch-Related Syncope

• Colivicchi F, Ammirati F, Biffi A, Verdile L, Pelliccia A, Santini M. Exercise-related syncope in young competitive athletes without evidence of structural heart disease. Clinical presentation and long-term outcome. Eur Heart J. 2002 Jul;23(14):1125-30.
  
  
• Calkins H, Seifert M, Morady F. Clinical presentation and long-term follow-up of athletes with exercise-induced vasodepressor syncope. Am Heart J. 1995 Jun;129(6):1159-64.
  
  
• Abe H, Iwami Y, Nakashima Y, Kohshi K, Kuroiwa A. Exercise-induced neurally mediated syncope. Jpn Heart J. 1997 Jul;38(4):535-9.
  
  
• Sakaguchi S, Shultz JJ, Remole SC, Adler SW, Lurie KG, Benditt DG. Syncope associated with exercise, a manifestation of neurally mediated syncope. Am J Cardiol. 1995 Mar 1;75(7):476-81.
  
  
• Noh CI, Song JY, Kim HS, Choi JY, Yun YS. Ventricular tachycardia and exercise related syncope in children with structurally normal hearts: emphasis on repolarisation abnormality.
  Br Heart J. 1995 Jun;73(6):544-7.
  
  
• Sturzenegger M, Newell DW, Douville CM, Byrd S, Schoonover KD, Nicholls SC. Transcranial Doppler and angiographic findings in adolescent stretch syncope.
  J Neurol Neurosurg Psychiatry. 1995 Mar;58(3):367-70. Review.
  
  
• Thompson PD. Tilt table testing in the evaluation and management of athletes with recurrent exercise-induced syncope. Med Sci Sports Exerc. 1993 Jul;25(7):883. No abstract available.
  
  

Course and Outcome

• Kouakam C, Vaksmann G, Pachy E, Lacroix D, Rey C, Kacet S. Long-term follow-up of children and adolescents with syncope; predictor of syncope recurrence.
  Eur Heart J. 2001 Sep;22(17):1618-25.
  
  
• Salim MA, Ware LE, Barnard M, Alpert BS, DiSessa TG. Syncope recurrence in children: relation to tilt-test results. Pediatrics. 1998 Oct;102(4 Pt 1):924-6.
  
  

Therapy

• Grubb BP. SSRIs for vasodepressor syncope? Postgrad Med. 2000 Nov;108(6):29, 32. No abstract available.
  
  
• Di Girolamo E, Di Iorio C, Leonzio L, Sabatini P, Barsotti A. Usefulness of a tilt training program for the prevention of refractory neurocardiogenic syncope in adolescents: A controlled study.
  Circulation. 1999 Oct 26;100(17):1798-801
  
  
• Younoszai AK, Franklin WH, Chan DP, Cassidy SC, Allen HD. Oral fluid therapy. A promising treatment for vasodepressor syncope.
  Arch Pediatr Adolesc Med. 1998 Feb;152(2):165-8.
  
  
• Lenk M, Alehan D, Ozme S, Celiker A, Ozer S. The role of serotonin re-uptake inhibitors in preventing recurrent unexplained childhood syncope -- a preliminary report.
  Eur J Pediatr. 1997 Oct;156(10):747-50.
  
  
• Deal BJ, Strieper M, Scagliotti D, Hulse E, Auld D, Campbell R, Strasburger JF, Benson DW Jr. The medical therapy of cardioinhibitory syncope in pediatric patients.
  Pacing Clin Electrophysiol. 1997 Jul;20(7):1759-61.
  
  
• Alehan D, Lenk M, Ozme S, Celiker A, Ozer S. Comparison of sensitivity and specificity of tilt protocols with and without isoproterenol in children with unexplained syncope. Pacing Clin Electrophysiol. 1997 Jul;20(7):1769-76.
  
  
• Rowe PC, Bou-Holaigah I, Kan JS, Calkins H. Is neurally mediated hypotension an unrecognised cause of chronic fatigue?
  Lancet. 1995 Mar 11;345(8950):623-4.
  
  
• Strieper MJ, Campbell RM. Efficacy of alpha-adrenergic agonist therapy for prevention of pediatric neurocardiogenic syncope.
  J Am Coll Cardiol. 1993 Aug;22(2):594-7.
  
  
• Grubb BP, Samoil D, Kosinski D, Kip K, Brewster P. Use of sertraline hydrochloride in the treatment of refractory neurocardiogenic syncope in children and adolescents.
  J Am Coll Cardiol. 1994 Aug;24(2):490-4.
  
  

Families

• Mathias CJ, Deguchi K, Bleasdale-Barr K, Smith S. Familial vasovagal syncope and pseudosyncope: observations in a case with both natural and adopted siblings.
  Clin Auton Res. 2000 Feb;10(1):43-5.
  
  

Psychology

• Byars KC, Brown RT, Campbell RM, Hobbs SA. Psychological adjustment and coping in a population of children with recurrent syncope.
  J Dev Behav Pediatr. 2000 Jun;21(3):189-97.
  

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